| Abstract: |
Green analytical chemistry represents a paradigm shift in pharmaceutical quality control by minimizing environmental impact while maintaining analytical performance. This study explores the development and validation of eco-friendly analytical methods for pharmaceutical analysis, focusing on reducing hazardous solvent consumption, waste generation, and energy utilization. The primary objective was to evaluate green chromatographic techniques, miniaturized analytical methods, and alternative solvents in pharmaceutical quality control. A comprehensive methodology involving HPLC with reduced organic solvent consumption, microextraction techniques, and supercritical fluid chromatography was employed. The hypothesis stated that eco-friendly methods would demonstrate comparable analytical performance to conventional methods while significantly reducing environmental impact. Results indicated that green methods achieved 60-85% reduction in solvent consumption with retention of analytical sensitivity and precision. Statistical analysis revealed excellent correlation coefficients (r>0.999) and recovery rates between 98-102%. Discussion highlighted the feasibility of implementing green analytical practices in routine pharmaceutical analysis. The study concludes that eco-friendly analytical methods offer sustainable alternatives for pharmaceutical quality control without compromising analytical integrity, supporting the pharmaceutical industry's transition toward environmental responsibility. |
